Preferred Label : LAIR-2 Fusion Protein NC410;
NCIt synonyms : Leukocyte-associated Immunoglobulin-like Receptor-2 Fusion Protein NC410;
NCIt related terms : NC-410;
NCIt definition : A fusion protein of leukocyte-associated immunoglobulin (Ig)-like receptor (LAIR)-2,
a high-affinity collagen receptor, with potential immunomodulatory and antineoplastic
activities. Upon administration, LAIR-2 fusion protein NC410 binds to the ligand collagen
of LAIR-1 (CD305), thereby blocking the binding of LAIR-1 to its ligand collagen and
inhibiting LAIR-1-mediated immune suppression. This may result in enhanced T-cell
and dendritic cell (DC) activities, and cytotoxic T-lymphocyte (CTL) and anti-tumor
immune responses. LAIR-1, a collagen-receptor and an inhibitory immune receptor belonging
to the Ig superfamily, is expressed on many peripheral blood mononuclear cells (PBMC)
including T-cells and DCs.;
UNII : I8YLE03D8B;
Molecule name : NC 410; NC-410;
NCI Metathesaurus CUI : CL1407327;
Origin ID : C173559;
UMLS CUI : C5418001;
Semantic type(s)
- concept_is_in_subset
- has_target
