Endostatin - CISMeF

Preferred Label : Endostatin;

NCIt related terms : COL18A1;

NCIt definition : Endostatin (183 aa, 20 kDa) is encoded by the human COL18A1 gene. This protein fragment is involved in the inhibition of both endothelial cell proliferation and blood vessel formation.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. COL18A1 is made from a type of collagen (a protein found in cartilage and other connective tissue). It may prevent the growth of new blood vessels that tumors need to grow. COL18A1 is a type of antiangiogenesis agent.;

NCIt note : Endostatin is a 20 kD C-terminal fragment of collagen XVIII that inhibits endothelial proliferation and angiogenesis. Cell surface proteoglycans glypican-1 and glypican-4 are endostatin receptors. Heparan sulfate glycosaminoglycans of glypican are critical for endostatin binding. Endostatin also promotes renal tubular cell branching morphogenesis. (from OMIM 120328 and NCI);

Codes from synonyms : CDR0000618576;

Details

Origin ID

C18046;

UMLS CUI

C3887702;

OMIM relation
- Collagen, type XVIII, alpha-1 [OMIM gene]
See also inter- (CISMeF)
- Collagen, type XVIII, alpha-1 [OMIM gene]
- collagen type XVIII alpha 1 chain [ORDO Gene]
- collagen type XVIII alpha 1 chain [HGNC gene]
- endostatins [MeSH Descriptor]
- endostatins [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
endogenous_product_related_to
- Recombinant Human Endostatin [NCIt concept]
gene_encodes_gene_product
- COL18A1 Gene [NCIt concept]
- Collagen Gene [NCIt concept]
- Extracellular Matrix Protein Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_has_biochemical_function
- Angiogenesis Inhibitory Protein [NCIt concept]
gene_product_has_chemical_classification
- Protein Fragment [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Morphogenesis [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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