Recombinant Human Endostatin

Preferred Label : Recombinant Human Endostatin;

NCIt synonyms : Recombinant Endostatin; rhEndostatin; N-Terminal-MGGSHHHHH-Endostatin (Human Recombinant);

NCIt related terms : Endostatin;

NCIt definition : A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis and inhibits endothelial proliferation and angiogenesis, which may result in a reduction in tumor burden. This agent also may decrease hepatic metastasis by inhibiting proinflammatory cytokines and vascular cell adhesion molecule (VCAM)-dependent cell attachment to the hepatic microvasculature. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. Endostatin is made from a type of collagen (a protein found in cartilage and other connective tissue). It may prevent the growth of new blood vessels that tumors need to grow. Endostatin is a type of antiangiogenesis agent.;

UNII : 67RHC0R671;

Drug name : Endostar;

Codes from synonyms : CDR0000044877; 09569;

Details

Origin ID

C45515;

UMLS CUI

C1705207;

See also inter- (CISMeF)
- Collagen, type XVIII, alpha-1 [OMIM gene]
- collagen type XVIII alpha 1 chain [ORDO Gene]
- collagen type XVIII alpha 1 chain [HGNC gene]
- endostatins [MeSH Descriptor]
- endostatins [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Endothelial Cell [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Unknown Cellular or Molecular Mechanism [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_related_to_endogenous_product
- Endostatin [NCIt concept]

Keyword's position in hierarchy(ies) :

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