Endotrophin - CISMeF

Preferred Label : Endotrophin;

NCIt synonyms : PRO-C6; COL6A3 Cleaved C5 Fragment; COL6A3 C-Terminal Kunitz Domain; COL6A3 Carboxyterminal C5 Domain; ETP; C-terminal Pro-Peptide of the Alpha 3 Type VI Collagen Chain; COL6A3 Carboxy Terminal C5 Domain; Collagen VI Alpha 3 C5; Collagen Alpha-3(VI) C-Terminal Peptide;

NCIt definition : Endotrophin is encoded by the human COL6A3 gene. This protein is involved in macrophage infiltration, fibrosis and epithelial-mesenchymal transition.;

NCIt note : Endotropin is a C-terminal fragment of collagen alpha-3(VI) chain that may be released through processing by the metalloproteinase bone morphogenetic protein 1. (JBC. 2019. 294:13769-13780.);

Details

Origin ID

C180396;

UMLS CUI

C4077444;

Automatic exact mappings (from CISMeF team)
- endotrophin [MeSH Supplementary Concept]
- endotrophin [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- COL6A3 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- COL6A3 Gene [NCIt concept]
- Collagen Gene [NCIt concept]
- Extracellular Matrix Protein Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_has_chemical_classification
- Protein Fragment [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Epithelial-to-Mesenchymal Transition [NCIt concept]
- Inflammatory Response [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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