Somatostatin Receptor Type 4

Preferred Label : Somatostatin Receptor Type 4;

NCIt synonyms : SSTR4; Somatostatin Receptor-4; Somatostatin Receptor 4; SS4-R; SS-4-R; SS4R;

NCIt definition : Somatostatin receptor type 4 (388 aa, 42 kDa) is encoded by the human SSTR4 gene. This protein plays a role in the inhibition of proliferation, stimulation of arachidonate release and activation of the mitogen-activated protein (MAP) kinase cascade.;

NCIt note : Somatostatin receptor 4 (SSTR4) is specifically expressed in human fetal and adult brain, lung, and stomach, and less in kidney, pituitary, and adrenals. SSTR4 also activates arachidonate release and the MAP kinase cascade. (OMIM 182454 and SWISS-PROT P31391);

Details

Origin ID

C17987;

UMLS CUI

C1568999;

Automatic exact mappings (from CISMeF team)
- Somatostatin receptor 4 [OMIM gene]
- somatostatin receptor 4 [HGNC gene]
- somatostatin receptor subtype-4 [MeSH concept]
- somatostatin receptor subtype-4 [MeSH Supplementary Concept]
OMIM relation
- Somatostatin receptor 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- SSTR4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- SSTR4 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Protein Hormone Receptor [NCIt concept]
- Somatostatin Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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