Two Pore Channel Protein 2

Preferred Label : Two Pore Channel Protein 2;

NCIt synonyms : Two Pore Segment Channel 2; Two-Pore Segment Channel 2; Two-Pore Channel 2; Voltage-Dependent Calcium Channel Protein TPC2; TPCN2; Two Pore Calcium Channel Protein 2;

NCIt definition : Two pore channel protein 2 (752 aa, 85 kDa) is encoded by the human TPCN2 gene. This protein is involved in voltage-gated transport of calcium ions across lysosomal membranes.;

NCIt note : Two pore calcium channel protein 2 plays a role in endocytosis of coronaviruses SARS-CoV, SARS-CoV-2 and HCoV-EMC. (UniProt);

Details

Origin ID

C179840;

UMLS CUI

C2355196;

Automatic exact mappings (from CISMeF team)
- Two-pore segment channel 2 [OMIM gene]
- two pore segment channel 2 [HGNC gene]
OMIM relation
- Two-pore segment channel 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TPCN2 protein, human [MeSH Supplementary Concept]
- TPCN2 protein, human [MeSH concept]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Ion Channel Protein Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- TPCN2 Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Calcium Channel [NCIt concept]
- Cellular Membrane [NCIt concept]
- Gated Ion Channel [NCIt concept]
- Ion Channel [NCIt concept]
- Membrane of the Lysosome [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Mediated Endocytosis [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients