Interleukin-1 Receptor-Like 2

Preferred Label : Interleukin-1 Receptor-Like 2;

NCIt synonyms : Interleukin 1 Receptor Like 2; IL36 Receptor; Interleukin 1 Receptor-Like 2; Interleukin-1 Receptor-Related Protein 2; EC 3.2.2.6; Interleukin 36 Receptor; IL1RL2; IL36R; IL-36 Receptor; Interleukin-36 Receptor; IL-36R; IL-1 Receptor-Related Protein 2; IL-1Rrp2; Interleukin-36-Receptor; IL1R-Rp2;

NCIt definition : Interleukin-1 receptor-like 2 (575 aa, 65 kDa) is encoded by the human IL1RL2 gene. This protein is involved in interleukin-36 signaling and the reversible oxidation of nicotinamide adenine dinucleotide (NAD) yielding nicotinamide and ADP-ribose.;

NCIt note : Following binding of an interleukin-36 (IL36) receptor agonist (IL36A, IL36B or IL36G), interleukin-1 receptor-like 2 (IL1L2) forms a complex with coreceptor interleukin-1 receptor accessory protein (IL1RAP) to activate IL36-dependent signaling pathways. Binding of the receptor antagonist interleukin-36 receptor antagonist protein (IL36RN or IL36RA) inhibits both recruitment of the IL1RAP coreceptor and signaling. (UniProt);

NCI Metathesaurus CUI : CL1374685;

Details

Origin ID

C178667;

UMLS CUI

C1700957;

Automatic exact mappings (from CISMeF team)
- Interleukin 1 receptor-like 2 [OMIM gene]
- interleukin 1 receptor like 2 [HGNC gene]
- receptors, interleukin-1 type ii [MeSH Descriptor]
OMIM relation
- Interleukin 1 receptor-like 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL1RAP protein, human [MeSH Supplementary Concept]
- IL1RAP protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- IL1RL2 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Immunoglobulin Family Protein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Imsidolimab [NCIt concept]

Keyword's position in hierarchy(ies) :

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