NCIt definition : A humanized monoclonal antibody directed against the interleukin-36 receptor (IL-36R),
with potential anti-inflammatory and immunomodulatory activities. Upon administration,
imsidolimab targets, binds to and prevents the activity of IL-36R by the pro-inflammatory
cytokine IL-36. This prevents IL-36/IL-36R-mediated signaling pathways. This may inhibit
skin inflammation in which the IL-36/IL-36R plays a key role. IL-36 is highly upregulated
in certain skin inflammatory conditions.;
UNII : KX89J0DFZ8;
CAS number : 2102543-86-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2102543-86-0
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G-SRS /a ;
Semantic type(s)