Serpin B5 - CISMeF

Preferred Label : Serpin B5;

NCIt synonyms : SERPINB5; Protease Inhibitor 5; PI5; Maspin; PI-5;

NCIt definition : Serpin B5 (375 aa, 42 kDa) is encoded by the human SERPINB5 gene. This protein plays a role in the regulation of cell movement and in tumor suppression.;

NCIt note : Maspin is a member of the Serpin protein family. Unlike other members of the family, Maspin exhibits no protease inhibitory activity (see J Biol Chem. 2002 Dec 6;277(49):46845-8. Epub 2002 Oct 15), but it plays a role in cell-matrix adhesion, tumor invasion, and metastasis. High maspin expression appears to oppose lymph node metastasis. Higher expression is associated with better survival rates and may be a favorable prognostic marker. (from SWISS-PROT, OMIM);

Details

Origin ID

C17790;

UMLS CUI

C1568102;

Currated CISMeF NLP mapping
- SERPIN-B5 [MeSH concept]
- SERPIN-B5 [MeSH Supplementary Concept]
OMIM relation
- Protease inhibitor 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SERPIN-B5 [MeSH concept]
- SERPIN-B5 [MeSH Supplementary Concept]
- SERPINB5 protein, human [MeSH concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- SERPINB5 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Mammary Epithelium [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Serpin [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
- Metastasis and Aggressiveness Marker [NCIt concept]
- Prognostic Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Motility [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Metastasis Suppression [NCIt concept]

Keyword's position in hierarchy(ies) :

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