Myeloblastin - CISMeF

Preferred Label : Myeloblastin;

NCIt synonyms : AGP7; ACPA; Wegener Autoantigen; MBT; PR-3; C-ANCA Antigen; NP-4; Proteinase-3; PR3; Azurophil Granule Protein 7; Neutrophil Serine Proteinase; PRTN3; C-ANCA; Neutrophil Proteinase 4; Leukocyte Proteinase 3; Serine Proteinase, Neutrophil; EC 3.4.21.76; P29;

NCIt related terms : PROTEINASE 3; Wegener Granulomatosis Autoantigen;

NCIt definition : Myeloblastin (256 aa, 28 kDa) is encoded by the human PRTN3 gene. This protein is involved in the proteolysis of extracellular matrix proteins.;

Alternative definition : CDISC: An antigen encoded by the PRTN3 gene that regulates extracellular matrix protein proteolysis. It can be considered as an autoantigen and is commonly associated with the autoimmune systemic vasculitis disease, Wegener's granulomatosis.;

Details

Origin ID

C17548;

UMLS CUI

C1706063;

Currated CISMeF NLP mapping
- Proteinase 3 [LOINC component]
- myeloblastin [MeSH Descriptor]
- myeloblastin [MeSH concept]
False automatic mappings
- Myeloblastin (substance) [SNOMED CT concept]
OMIM relation
- Proteinase 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- PRTN3 Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Neutrophil [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_malfunction_associated_with_disease
- Granulomatosis with Polyangiitis [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- PR1 Leukemia Peptide Vaccine [NCIt concept]
- Proteinase 3:PR1 Peptide [NCIt concept]

Keyword's position in hierarchy(ies) :

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