Tissue Inhibitor of Metalloproteinases

Preferred Label : Tissue Inhibitor of Metalloproteinases;

NCIt synonyms : TIMP;

NCIt definition : Tissue inhibitors of metalloproteinase. A family of proteins of around 200 residues that can inhibit enzymes of the metalloprotease type, for example collagenase, by binding to them. (DCB-CB);

NCIt note : TIMP family members may possess selective affinities for matrix metalloproteinases. The N-terminus is responsible for MMP inhibition; the C-terminus mediates specific molecular functions.;

Details

Origin ID

C17544;

UMLS CUI

C0145988;

Currated CISMeF NLP mapping
- tissue inhibitor of metalloproteinases [MeSH Descriptor]
- tissue inhibitor of metalloproteinases [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Test of Infant Motor Performance (TIMP) [LOINC Class]
- tissue inhibitor of metalloproteinases [MeSH concept]
- tissue inhibitor of metalloproteinases [MeSH Descriptor]
gene_encodes_gene_product
- Enzyme Inhibitor Gene [NCIt concept]
- Proteinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Enzyme Inhibition [NCIt concept]
- Protein Degradation Inhibition [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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