tissue inhibitor of metalloproteinases

Preferred Label : tissue inhibitor of metalloproteinases;

MeSH definition : A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.;

MeSH synonym : metalloproteinases tissue inhibitor; TIMP proteins; proteins, TIMP; Tissue Inhibitor of Metalloproteinase; Metalloproteinase Tissue Inhibitor;

CISMeF synonym : timp;

Related MeSH term : collagenase inhibitor; inhibitor, collagenase;

MeSH annotation : general or unspecified; prefer specifics;

Wikipedia link : https://en.wikipedia.org/wiki/Tissue inhibitor of metalloproteinases;

Is substance : O;

Details

Origin ID

D019714;

UMLS CUI

C0145988;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Pharmacological action(s)
- matrix metalloproteinase inhibitors [MeSH Descriptor]
Record concept(s)
- tissue inhibitor of metalloproteinases [MeSH concept]
Related MeSH Supplementary Concept(s)
- TIMP protein, crassostrea gigas [MeSH Supplementary Concept]
- cri-2 protein, C elegans [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Test of Infant Motor Performance (TIMP) [LOINC Class]
- Tissue Inhibitor of Metalloproteinases [NCIt concept]
Validated automatic mappings to BTNT
- Tissue inhibitor of metalloproteinases 1 [LOINC component]

Keyword's position in hierarchy(ies) :

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