Insulin-Like Growth Factor Receptor

Preferred Label : Insulin-Like Growth Factor Receptor;

NCIt synonyms : IGF Receptor; Insulin-Like Growth Factor Receptor Family;

NCIt related terms : IGFR;

NCIt definition : A transmembrane protein expressed on the surface of target cells that is specific for binding insulin-like growth factor (IGF) proteins. There are two IGF receptors, one of which has receptor tyrosine kinase activity similar to insulin receptor (INSR).;

Alternative definition : NCI-GLOSS: A protein found on the surface of some types of cells that binds to insulin-like growth factor (IGF). This causes the cells to grow and divide. Insulin-like growth factor receptor is found at high levels on the surface of several types of cancer cells, which causes these cells to grow rapidly in the presence of IGF.;

Codes from synonyms : CDR0000653123; CDR0000653124;

Details

Origin ID

C17530;

UMLS CUI

C0140079;

Automatic exact mappings (from CISMeF team)
- insulin like growth factor 1 receptor [ORDO Gene]
- receptor, igf type 1 [MeSH Descriptor]
- receptor, igf type 2 [MeSH Descriptor]
- receptors, somatomedin [MeSH Descriptor]
- receptors, somatomedin [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- receptors, somatomedin [MeSH concept]
- receptors, somatomedin [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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