receptor, igf type 1

Preferred Label : receptor, igf type 1;

MeSH definition : A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.;

MeSH synonym : receptor, igf-1; receptor, insulin-like growth factor type 1; receptors, igf-1; receptors, insulin-like-growth factor i; igf-i receptor; igf-1 receptor; igf-1 receptors; insulin like growth factor i receptor; igf i receptor; insulin-like-growth factor i receptor; receptor, igf i; igf 1 receptor; receptor, igf-i; receptor, insulin-like growth factor i; receptors, igf 1; igf type 1 receptor;

CISMeF synonym : EC 2.7.1.112; EC 2.7.11.-;

MeSH hyponym : receptor, IGF type 1 alpha subunit; receptor, IGF type 1 beta subunit;

Registry Number MeSH : EC 2.7.10.1;

MeSH annotation : DF: RECEPT IGF 1;

Is substance : O;

UNII : EC 2.7.10.1;

Details

Origin ID

D017526;

UMLS CUI

C0140080;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- Anti-IGF1R Monoclonal Antibody [NCIt concept]
Indexing information
- 4-(1-(2-(4-((2-(4-chloro-1H-pyrazol-1-yl)ethyl)amino)-2-oxo-1,2-dihydropyridin-3-yl)-4-methyl-1H-benzo(d)imidazol-6-yl)piperidin-4-yl)piperazine-1-carboxylate [MeSH Supplementary Concept]
- 4-(4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo(f)(1,4)oxazepin-3-ylmethyl)phenol [MeSH Supplementary Concept]
- AZ 12253801 [MeSH Supplementary Concept]
- GSK 1838705A [MeSH Supplementary Concept]
- GTx 134 [MeSH Supplementary Concept]
- M1557 peptide [MeSH Supplementary Concept]
- N4-(3-cyclopropyl-1H-pyrazol-5-yl)-5-fluoro-N2-(4-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine [MeSH Supplementary Concept]
- cixutumumab [MeSH Supplementary Concept]
Record concept(s)
- receptor, IGF type 1 [MeSH concept]
- receptor, IGF type 1 alpha subunit [MeSH concept]
- receptor, IGF type 1 beta subunit [MeSH concept]
Related MeSH Supplementary Concept(s)
- IGF1R protein, human [MeSH Supplementary Concept]
- Igf1r protein, mouse [MeSH Supplementary Concept]
- Igf1r protein, rat [MeSH Supplementary Concept]
See also
- insulin-like growth factor i [MeSH Descriptor]
- insulin-like growth factor ii [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- Insulin-like growth factor-I receptor [LOINC component]

Keyword's position in hierarchy(ies) :

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