Preferred Label : Insulin-Like Growth Factor-Binding Protein 3;
NCIt synonyms : IGF Binding Protein 3; IGFBP-3; IGFBP3; Insulin-Like Growth Factor Binding Protein 3; Binding Protein 29; IGF-Binding Protein 3; IBP-3; Growth Hormone-Dependent Binding Protein; Insulin-Like Growth Factor-Binding Protein-3; Acid Stable Subunit of The 140 k IGF Complex; Binding Protein 53;
NCIt definition : Insulin-like growth factor-binding protein 3 (291 aa, 32 kDa) is encoded by the human
IGFBP3 gene. This protein plays a role in insulin-like growth factor signaling, apoptosis
promotion, and cell proliferation inhibition.;
NCIt note : IGFBP3 belongs to the IGFBP family. IGFBP3 functions as the major carrying protein
for IGF1 and IGF2 in the circulation, modulates IGF activity, and inhibits cell growth.
IGFBP3 binds IGF-II more than IGF-I. Endothelial IGFBP3 forms a ternary complex with
IGF-I or IGF-II and an 85 kD glycoprotein (ALS). IGFBP3 levels increase in the presence
of IGF-I, insulin and other growth-stimulating factors such as growth hormone, epidermal
growth factor, and phorbol esters. IGFBP3 may control angiogenesis and cell responses
in the corpus luteum by autocrine/paracrine mechanisms. IGFBP3 also possesses growth-inhibitory
and -potentiating effects that are independent of IGF and are mediated through specific
receptors. As a specific IGFBP3-binding protein, transferrin blocks IGFBP3-induced
cell proliferation and IGFBP3-induced apoptosis. (OMIM, SwissProt);
Origin ID : C17509;
UMLS CUI : C1872103;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_structural_domain_or_motif
- gene_product_is_biomarker_type
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
