Insulin-Like Growth Factor-Binding Protein 1

Preferred Label : Insulin-Like Growth Factor-Binding Protein 1;

NCIt synonyms : IGFBP-1; Placental Protein 12; Binding Protein-25; Binding Protein-28; IGF Binding Protein 1; Insulin-Like Growth Factor Binding Protein 1; IGFBP1; AFBP; IBP-1; Growth Hormone Independent-Binding Protein; Amniotic Fluid Binding Protein; Alpha-Pregnancy-Associated Endometrial Globulin; PP12; Binding Protein-26; Insulin-Like Growth Factor-Binding Protein-1; IGF-Binding Protein 1;

NCIt definition : Insulin-like growth factor-binding protein 1 (259 aa, 28 kDa) is encoded by the human IGFBP1 gene. This protein is involved in cell migration and both insulin-like growth factor binding and signaling.;

NCIt note : IGFBP1 belongs to the IGFBP family. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. Secreted IGFBPs prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs. They alter the interaction of IGFs with cell surface receptors. IGFBP1 is synthesized in liver, secretory endometrium and decidua. It binds IGF-I and IGF-II with equal affinity and phosphorylation alters its affinity for IGFs. IGFBP1 potentiates IGF-I action and its C-terminal RGD sequence may account for its ability to attach to cells and potentiate IGF-I action. IGFBP1 may act as a paracrine regulator of cell growth.; Encoded by human IGFBP1 Gene and expressed in liver, endometrium, and decidua, low molecular weight secreted 259-aa 29-kD Insulin-Like Growth Factor-Binding Protein 1 precursor contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP1 binds equally to plasma IGF I and IGF II with high affinity. The protein has 15 N- and C-terminal cysteines and a C-terminal RGD sequence that may promote potentiation of IGF I biologic actions. IGFBP1 is probably phosphorylated by casein kinase II, which alters IGF affinity. IGF-binding proteins prolong the half-life of IGFs and alter IGF interactions with cell surface receptors.;

Details

Origin ID

C17505;

UMLS CUI

C0071189;

Automatic exact mappings (from CISMeF team)
- Insulin-Like growth factor binding protein 1 [OBSOLETE LOINC component]
- Insulin-like growth factor binding protein 1 [LOINC component]
- Insulin-like growth factor-binding protein 1 [OMIM gene]
- immunoglobulin binding protein 1 [ORDO Gene]
- insulin like growth factor binding protein 1 [HGNC gene]
Currated CISMeF NLP mapping
- Insulin-Like growth factor binding protein 1 [MeSH Descriptor]
- Insulin-Like growth factor binding protein 1 [MeSH concept]
False automatic mappings
- Insulin-like growth factor binding protein 1 (substance) [SNOMED CT concept]
OMIM relation
- Insulin-like growth factor-binding protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IGFBP1 protein, human [MeSH concept]
- IGFBP1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- IGFBP1 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Endometrium [NCIt concept]
- Liver [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Risk Marker [NCIt concept]
gene_product_is_element_in_pathway
- FOXA2 and FOXA3 Transcription Factor Signaling Pathway [NCIt concept]
- Food Intake and Energy Homeostasis Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Intracellular Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Signal Transduction [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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