Insulin-Like growth factor binding protein 1

Preferred Label : Insulin-Like growth factor binding protein 1;

MeSH definition : One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29);

MeSH synonym : igfbp-1; igf-binding protein 1; igf binding protein 1; insulin like growth factor binding protein 1;

MeSH annotation : /biosyn /drug eff /physiol /ultrastruct permitted; DF: note short X refs;

Is substance : O;

Details

Origin ID

D018970;

UMLS CUI

C0123256;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Insulin-Like Growth Factor-Binding Protein 1 [NCIt concept]
- Insulin-like growth factor binding protein 1 [LOINC component]
- Insulin-like growth factor binding protein 1 (substance) [SNOMED CT concept]
Record concept(s)
- Insulin-Like growth factor binding protein 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- IGFBP1 protein, human [MeSH Supplementary Concept]
- IGFBPL-1 protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Insulin-like growth factor binding protein 1 [LOINC component]
- Insulin-like growth factor binding protein 1 (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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