FOS Oncoprotein

Preferred Label : FOS Oncoprotein;

NCIt synonyms : Cellular Oncogene c-FOS; G0S7 Protein;

NCIt definition : c-FOS protein is a transcription factor critical in regulating the development of the skeleton. c-FOS protein is a major component of the DNA-binding AP-1 transcription complex, which also includes members of the JUN family. Each protein contains a bZIP domain and a leucine zipper domain. FOS oncoproteins derive from mutated FOS genes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses, which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a 55 kD protein and the FBR-MSV v-fos gene encodes a 75 kD fusion protein. (from OMIM 164810 and NCI);

Details

Origin ID

C17439;

UMLS CUI

C0085301;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Proto-Oncogene proteins c-fos [MeSH concept]
- Proto-Oncogene proteins c-fos [MeSH Descriptor]
gene_encodes_gene_product
- Oncogene [NCIt concept]
- Oncogene FOS [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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