Talquetamab - CISMeF

Preferred Label : Talquetamab;

NCIt synonyms : GPRC5D x CD3 Bispecific Antibody JNJ-64407564; Humanized GPRC5D x CD3 DuoBody Antibody JNJ-64407564; GPRC5D/CD3 DuoBody Antibody JNJ-64407564; GPRC5D x CD3 DuoBody Antibody JNJ-64407564; Anti-CD3/Anti-GPRC5D Bispecific Monoclonal Antibody JNJ-64407564; Talquetamab-tgvs;

NCIt definition : A bispecific humanized monoclonal antibody against human CD3, a T-cell surface antigen, and human G-protein coupled receptor family C group 5 member D (GPRC5D), a tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, talquetamab binds to both CD3 on T-cells and GPRC5D expressed on certain tumor cells. This results in the cross-linking of T-cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against GPRC5D-expressing tumor cells. GPRC5D is overexpressed on certain tumors, such as multiple myeloma, while minimally expressed on normal, healthy cells, and plays a key role in tumor cell proliferation.;

UNII : 4W3KFI3TN3;

CAS number : 2226212-40-2;

Molecule name : JNJ 64407564; JNJ-64407564;

NCI Metathesaurus CUI : CL545429;

Codes from synonyms : 111584;

Origin ID

C171840;

UMLS CUI

C5419330;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- talquetamab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- G-Protein Coupled Receptor Family C Group 5 Member D [NCIt concept]
is_component_of_chemotherapy_regimen
- Talquetamab Regimen [NCIt concept]

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