DNA Topoisomerase 1 Cleavable Complex

Preferred Label : DNA Topoisomerase 1 Cleavable Complex;

NCIt synonyms : TOPI Cleavable Complex; Topoisomerase 1 Cleavable Complex; TOP1-DNA Intermediate; Top1 Cleavable Complex; Topo I Cleavable Complex; DNA Topoisomerase I Cleavable Complex; Topoisomerase I Cleavable Complex;

NCIt definition : A complex between the enzyme DNA topoisomerase 1 (TOP1) and its DNA substrate. Under normal conditions these complexes are transient and found at low levels. In the presence of therapeutic TOP1 inhibitors these complexes are stabilized, which prevents DNA religation and induces lethal DNA strand breaks.;

NCI Metathesaurus CUI : CL1405856;

Details

Origin ID

C171629;

UMLS CUI

C5419223;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
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- Cositecan [NCIt concept]
- Daunorubicin [NCIt concept]
- Daunorubicin Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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