" /> Cositecan - CISMeF





Preferred Label : Cositecan;

NCIt synonyms : Karenitecin; (4S)-4-Ethyl-4-hydroxy-11-(2-(trimethylsilyl)ethyl)-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione;

NCIt definition : A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Cositecan stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, cositecan exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins.;

Alternative definition : NCI-GLOSS: A drug being studied in the treatment of cancer. It belongs to a family of drugs called topoisomerase inhibitors. It is related to the anticancer drug camptothecin.;

UNII : 24R60NVC41;

InChIKey : POADTFBBIXOWFJ-VWLOTQADSA-N;

CAS number : 203923-89-1;

Molecule name : DB 172; BNP1350;

Chemical formula : C25H28N2O4Si;

NSC code : 710270;

Codes from synonyms : CDR0000045003;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
30/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.