" /> Cositecan - CISMeF





Preferred Label : Cositecan;

NCIt synonyms : Karenitecin; (4S)-4-Ethyl-4-hydroxy-11-(2-(trimethylsilyl)ethyl)-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione;

NCIt definition : A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Cositecan stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, cositecan exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins.;

Alternative definition : NCI-GLOSS: A drug being studied in the treatment of cancer. It belongs to a family of drugs called topoisomerase inhibitors. It is related to the anticancer drug camptothecin.;

UNII : 24R60NVC41;

InChIKey : POADTFBBIXOWFJ-VWLOTQADSA-N;

CAS number : 203923-89-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 203923-89-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : DB 172; BNP1350;

Chemical formula : C25H28N2O4Si;

NSC code : 710270;

Codes from synonyms : CDR0000045003;

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15/05/2024


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