Acoramidis - CISMeF

Preferred Label : Acoramidis;

NCIt synonyms : TTR Stabilizer AG10; Transthyretin Stabilizer AG10;

NCIt definition : A potent, highly selective, orally bioavailable transthyretin (TTR) stabilizer with potential disease-modifying activity. Upon oral administration, acoramidis binds to and stabilizes transthyretin (TTR), thereby preventing tetramer dissociation into monomers. This prevents misfolding of the TTR protein and inhibits the formation of TTR amyloid fibrils and the subsequent deposition of these insoluble protein clusters in the heart and peripheral nerves. TTR is a 127 amino acid transport protein for thyroxine and retinol and is secreted by the liver into the blood. The accumulation of TTR amyloid fibrils may result in thickening and stiffening of the ventricular wall, leading to heart failure.;

UNII : T12B44A1OE;

InChIKey : WBFUHHBPNXWNCC-UHFFFAOYSA-N;

CAS number : 1446711-81-4;

Molecule name : AG-10; AG 10;

NCI Metathesaurus CUI : CL1383184;

Details

Origin ID

C170791;

UMLS CUI

C5418800;

Currated CISMeF NLP mapping
- 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid [MeSH concept]
- 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid [MeSH Supplementary Concept]
- Acoramidis [SMS substance]
Manual BTNT mappings - CISMeF
- acoramidis [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Transthyretin [NCIt concept]

Keyword's position in hierarchy(ies) :

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