Acoramidis Hydrochloride

Preferred Label : Acoramidis Hydrochloride;

NCIt synonyms : AG10 Hydrochloride; ALXN2060 Hydrochloride;

NCIt related terms : Attruby;

NCIt definition : The hydrochloride salt form of acoramidis, a potent, highly selective, orally bioavailable transthyretin (TTR) stabilizer with potential disease-modifying activity. Upon oral administration, acoramidis binds to and stabilizes transthyretin (TTR), thereby preventing tetramer dissociation into monomers. This prevents misfolding of the TTR protein and inhibits the formation of TTR amyloid fibrils and the subsequent deposition of these insoluble protein clusters in the heart and peripheral nerves. TTR is a transport protein for thyroxine and retinol and is secreted by the liver into the blood. The accumulation of TTR amyloid fibrils may result in thickening and stiffening of the ventricular wall, leading to heart failure.;

UNII : VY9C88C2NV;

CAS number : 2242751-53-5;

Drug name : Attruby;

NCI Metathesaurus CUI : CL1648537;

Details

Origin ID

C179070;

UMLS CUI

C5555442;

Currated CISMeF NLP mapping
- Acoramidis hydrochloride [SMS substance]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Acoramidis [NCIt concept]
is_salt_form_of
- Acoramidis [NCIt concept]

Keyword's position in hierarchy(ies) :

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