Integrin Alpha-X

Preferred Label : Integrin Alpha-X;

NCIt synonyms : Antigen Cd11c (P150), Alpha Polypeptide; Alphax Integrin Chain; Myeloid Membrane Antigen, Alpha Subunit; Axb2; Leukocyte Surface Antigen P150, 95; ITGAX; Cr4; Leukocyte Adhesion Glycoprotein P150,95, Alpha Chain; p150 95 Integrin Alpha Chain; Integrin Alpha X; Leu M5; Leukocyte Adhesion Receptor P150,95; CD11 Antigen-Like Family Member C;

NCIt related terms : CD11c;

NCIt definition : Integrin alpha-X (1163 aa, 128 kDa) is encoded by the human ITGAX gene. This protein is involved in cell-matrix interactions and integrin signaling.;

NCIt note : Integrin alpha-X forms a non-covalent complex with integrin beta-2 (ITGB2 or CD18) to form a leukocyte-specific integrin called inactivated-C3b (iC3b) receptor 4 (CR4).;

Details

Origin ID

C16789;

UMLS CUI

C4082262;

OMIM relation
- Integrin, alpha-X [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- ITGAX Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Leukocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- CD11 Protein Family [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Dendritic Cell Pathway [NCIt concept]
gene_product_is_physical_part_of
- Integrin [NCIt concept]
gene_product_malfunction_associated_with_disease
- Leukocyte Adhesion Deficiency Type 1 [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Heterodimerization [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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