integrin alpha chains

Preferred Label : integrin alpha chains;

MeSH definition : The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.;

MeSH synonym : alpha chains, integrin; integrin alpha subunits; alpha integrins; integrins, alpha;

Is substance : O;

Details

Origin ID

D039001;

UMLS CUI

C1136252;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CD11c Ag [LOINC component]
- ITGAE wt Allele [NCIt concept]
- ITGAX wt Allele [NCIt concept]
- Integrin Alpha-E [NCIt concept]
- Integrin, alpha-e [OMIM gene]
Record concept(s)
- integrin alpha chains [MeSH concept]
Related MeSH Supplementary Concept(s)
- CDw49d [MeSH Supplementary Concept]
- ITFG2 protein, human [MeSH Supplementary Concept]
- ITGA11 protein, human [MeSH Supplementary Concept]
- ITGA11 protein, rat [MeSH Supplementary Concept]
- ITGA8 protein, human [MeSH Supplementary Concept]
- ITGAD protein, human [MeSH Supplementary Concept]
- ITGAX protein, human [MeSH Supplementary Concept]
- Itfg2 protein, mouse [MeSH Supplementary Concept]
- Itga11 protein, mouse [MeSH Supplementary Concept]
- Itga5 protein, mouse [MeSH Supplementary Concept]
- Itgad protein, mouse [MeSH Supplementary Concept]
- alpha E integrins [MeSH Supplementary Concept]
- alpha PS3 integrin, drosophila [MeSH Supplementary Concept]
- if protein, drosophila [MeSH Supplementary Concept]
- integrin alpha 10 [MeSH Supplementary Concept]
- integrin alpha11, mouse [MeSH Supplementary Concept]
- integrin alpha7 [MeSH Supplementary Concept]
- integrin alpha8 [MeSH Supplementary Concept]
- integrin alpha9 [MeSH Supplementary Concept]
- integrin alphaD, mouse [MeSH Supplementary Concept]
- integrin alphaHr1, halocynthia roretzi [MeSH Supplementary Concept]
- integrin alphaP, strongylocentrotus purpuratus [MeSH Supplementary Concept]
- platelet receptor for collagen, deficiency of [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
Validated automatic mappings to BTNT
- Integrin Alpha-X [NCIt concept]

Keyword's position in hierarchy(ies) :

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