Proliferation-Associated Protein 2G4

Preferred Label : Proliferation-Associated Protein 2G4;

NCIt synonyms : ErbB-3 Binding Protein 1; Cell Cycle Protein p38-2G4 Homolog; PA2G4; ErbB3-Binding Protein 1; hG4-1; ErbB3-Binding Protein Ebp1; EBP1;

NCIt definition : Proliferation-associated protein 2G4 (394 aa, 44 kDa) is encoded by the human PA2G4 gene. This protein is involved in the regulation of RNA processing and apoptosis.;

NCIt note : Proliferation-associated protein 2G4 (PA2G4) has at least two isoforms (p48 and p42) produced by alternative splicing. PA2G4 p42 interact with the cytoplasmic domain of the receptor tyrosine-protein kinase erbB-3 and may contribute to transducing growth regulatory signals. (EntrezGene, OMIM, and Uniprot); Structurally, proliferation-associated protein 2G4 belongs to the peptidase M24 family; however, it does not contain metal cofactors and lacks aminopeptidase activity. (UniProt);

Details

Origin ID

C167154;

UMLS CUI

C5238314;

Automatic exact mappings (from CISMeF team)
- Proliferation-associated 2g4, 38-kd [OMIM gene]
OMIM relation
- Proliferation-associated 2g4, 38-kd [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PA2G4 protein, human [MeSH Supplementary Concept]
- PA2G4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- PA2G4 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleolus [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- RNA Recognition Motif [NCIt concept]
gene_product_is_element_in_pathway
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Survival [NCIt concept]
- Ligand Binding [NCIt concept]
- RNA Binding [NCIt concept]
- RNA Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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