Histone H2A - CISMeF

Preferred Label : Histone H2A;

NCIt synonyms : Histone-H2A; Histone 2A; HIST1H2A;

NCIt related terms : H2A;

NCIt definition : Slightly lysine rich histone. One of four histones assembled into a nucleosomal core octamer. Various posttranslationally modified forms and variants exist. Combines with histone H2B in a heterodimer; two H2A/H2B dimers are incorporated in the nucleosomal octamer.;

Alternative definition : CDISC: An antigen in the core histone family and a subunit of the nucleosome complex, with a designation of H2A. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases systemic lupus erythematosus and rheumatoid arthritis.;

Details

Origin ID

C16684;

UMLS CUI

C0019646;

Currated CISMeF NLP mapping
- Histone H2A [FMA entity]
- Histone H2a [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Histone H2A [FMA entity]
- Histone H2a [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- Histone Gene [NCIt concept]
- Histone H2 Gene [NCIt concept]
- Histone H2A Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Chromatin [NCIt concept]
- Nucleosome [NCIt concept]
- Nucleosome Core Particle [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Structural Process [NCIt concept]
- DNA Topology Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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