Histone H1 - CISMeF

Preferred Label : Histone H1;

NCIt synonyms : Histone-H1;

NCIt related terms : H1;

NCIt definition : Linker Histone H1 interacts with DNA between nucleosome units in mediating chromatin compaction into higher order structures. Histones are basic nuclear proteins responsible for the nucleosome structure of eukaryotic chromatin. Repeating nucleosome units contain two molecules each of core Histones H2A, H2B, H3, and H4 that form an octamer complex around which approximately 146 base pairs of DNA is wrapped. (NCI);

Alternative definition : CDISC: An antigen in the core histone family and a subunit of the nucleosome complex, with a designation of H1. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases systemic lupus erythematosus and rheumatoid arthritis.;

Details

Origin ID

C16683;

UMLS CUI

C0019644;

Automatic exact mappings (from CISMeF team)
- histones [MeSH Descriptor]
- vacuolar protein sorting 45 homolog [ORDO Gene]
Currated CISMeF NLP mapping
- Histone H1 [FMA entity]
- Histone H1 [MeSH concept]
False automatic mappings
- histone H1(s) [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Histone H1 [FMA entity]
- Histone H1 [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- Histone Gene [NCIt concept]
- Histone H1 Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Chromatin [NCIt concept]
- Nucleosome [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Chromatin Structural Process [NCIt concept]
- Chromosome Condensation [NCIt concept]
- DNA Binding [NCIt concept]
is_target
- Iodine I 131 Derlotuximab Biotin [NCIt concept]

Keyword's position in hierarchy(ies) :

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