Preferred Label : Iodine I 131 Derlotuximab Biotin;
NCIt synonyms : I 131 Monoclonal Antibody TNT-1/B; iodine I 131 MOAB TNT-1/B; I 131 MOAB TNT-1/B; I 131 Monoclonal Antibody TNT-1 B;
NCIt related terms : IODINE I-131 DERLOTUXIMAB BIOTIN;
NCIt definition : An iodine 131 labeled radioimmunoconjugate of monoclonal antibody (MOAB) TNT-1/B with
radioimaging and antineoplastic properties. MOAB TNT-1/B was developed for radioimmunotherapy
of solid tumors, designated as Tumor Necrosis Treatment (TNT). TNT exploits the presence
of degenerating and necrotic cells within tumors by utilizing MOAbs directed against
universal, intracellular nucleosomal determinants consisting of histone H1 and DNA.
This MOAB was conjugated with biotin (B) molecules, which increase pharmacokinetic
performance of the monoclonal antibody. Upon administration, iodine I 131 derlotuximab
biotin delivers I 131 to tumor cells and results in the targeted imaging and/or destruction
of cells with exposed necrotic antigens.;
UNII : 1724UJB90B;
CAS number : 340013-96-9;
Drug name : Cotara;
Origin ID : C2223;
UMLS CUI : C4764296;
Semantic type(s)
- concept_is_in_subset
- has_target
