DNA Polymerase Delta

Preferred Label : DNA Polymerase Delta;

NCIt synonyms : Delta DNA Polymerase; DNA Polymerase Delta Complex;

NCIt definition : A protein complex that has dual enzymatic activities in DNA synthesis. The enzyme complex both facilitates DNA synthesis by acting as a polymerase and exhibits exonuclease activity that degrades single stranded DNA in the 3' to 5' direction. It is a heterotetramer comprised of the DNA polymerase delta catalytic subunit and 3 DNA polymerase delta accessory subunits.;

NCIt note : DNA polymerase delta interaction with the proliferating cell nuclear antigen and the multisubunit replication factor C is essential for leading strand synthesis. (UniProt);

Details

Origin ID

C16511;

UMLS CUI

C0012890;

Automatic exact mappings (from CISMeF team)
- Polymerase (dna-directed), delta 1, catalytic subunit [OMIM gene]
- delta DNA polymerase complex [GO term]
Currated CISMeF NLP mapping
- DNA polymerase III [MeSH concept]
- DNA polymerase III [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DNA polymerase III [MeSH Descriptor]
- DNA polymerase III [MeSH concept]
gene_product_has_biochemical_function
- DNA-directed DNA Polymerase [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Replication Proofreading [NCIt concept]
- DNA Synthesis [NCIt concept]
- Excision Repair [NCIt concept]
has_gene_product_element
- DNA Polymerase Delta Catalytic Subunit [NCIt concept]
- DNA Polymerase Delta Subunit 3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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