NCIt definition : The active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic
acid. Metabolically active, l-leucovorin, also known levoleucovorin, does not require
bioactivation by dihydrofolate reductase, an enzyme inhibited by folic acid antagonists.
This agent may enhance the effects of fluoropyrimidines by stabilizing their binding
to the enzyme thymidylate synthase. (NCI04);
UNII : 990S25980Y;
InChIKey : VVIAGPKUTFNRDU-STQMWFEESA-N;
CAS number : 58-05-9;
Drug name : Isovorin; Elvorine, Isovorin, Levofolene, Levorin;