Preferred Label : 6 Melanoma Helper Peptide Vaccine;
NCIt synonyms : 6MHP Vaccine; 6MHP;
NCIt definition : A multi-epitope vaccine containing the following six class II MHC-restricted peptides:
gp100, MelanA/MART-1, two tyrosinase peptides, and the cancer/testis antigens MAGE-A3
and MAGE-A1,2,3,6, with potential antineoplastic activity. Upon administration, melanoma
helper peptides induce an antigen-specific, Th1-dominant, CD4 T-cell response, potentially
augmenting cytotoxic T-cell (CTL) responses and maintaining immunologic memory against
tumor cells expressing melanoma-specific antigens. The 6MHP vaccine may also induce
a CD8 T-cell response through epitope spreading, potentially priming subsequent immune
responses against tumor cells.;
NCI Metathesaurus CUI : CL554890;
Origin ID : C153515;
UMLS CUI : C4727312;
Semantic type(s)
- concept_is_in_subset
- has_target
