Aminocamptothecin

Preferred Label : Aminocamptothecin;

NCIt synonyms : 9-amino-CPT; 9-amino-camptothecin; 9-amino-20(S)-camptothecin; 9-amino-20-camptothecin; 9-AC;

NCIt related terms : 9-AMINOCAMPTOTHECIN; 9-Amino-20-(S)-camptothecin;

NCIt definition : A water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.;

UNII : 5MB77ICE2Q;

InChIKey : FUXVKZWTXQUGMW-FQEVSTJZSA-N;

CAS number : 86639-63-6;

NSC code : 603071;

Codes from synonyms : NSC0603071; CDR0000045399;

Details

Origin ID

C1488;

UMLS CUI

C0214192;

Currated CISMeF NLP mapping
- 9-aminocamptothecin [MeSH concept]
- 9-aminocamptothecin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 9-aminocamptothecin [MeSH Supplementary Concept]
- 9-aminocamptothecin [MeSH concept]
chemical_or_drug_affects_gene_product
- DNA Topoisomerase 1 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Replication Inhibition [NCIt concept]
- DNA Strand Break [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Aminocamptothecin/Filgrastim [NCIt concept]

Keyword's position in hierarchy(ies) :

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