GATOR Complex Protein DEPDC5

Preferred Label : GATOR Complex Protein DEPDC5;

NCIt synonyms : DEP Domain-Containing Protein 5; DEPDC5;

NCIt definition : GATOR complex protein DEPDC5 (1603 aa, 181 kDa) is encoded by the human DEPDC5 gene. This protein plays a role in the inhibition of Ras-related GTP-binding protein-mediated signaling.;

NCIt note : DEPDC5, NPRL2 and NPRL3 are subunits of the GATOR1 (GAP Activity TOward Rags 1) complex, which inhibits the amino acid-sensing branch of the mTORC1 pathway.;

Details

Origin ID

C148377;

UMLS CUI

C3849647;

Automatic exact mappings (from CISMeF team)
- DEP domain containing 5, GATOR1 subcomplex subunit [ORDO Gene]
- Dep domain-containing protein 5 [OMIM gene]
OMIM relation
- Dep domain-containing protein 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- DEPDC5 protein, human [MeSH concept]
- DEPDC5 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- DEPDC5 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
- Membrane of the Lysosome [NCIt concept]
gene_product_is_element_in_pathway
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Autophagy [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Signal Transduction Induction [NCIt concept]
- Stress Response Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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