Kell Blood Group Glycoprotein

Preferred Label : Kell Blood Group Glycoprotein;

NCIt synonyms : KEL; CD238; EC 3.4.24.-; Kell Blood Group Antigen; CD238 Antigen; Kell Glycoprotein;

NCIt definition : Kell blood group glycoprotein (732 aa, 83 kDa) is encoded by the human KEL gene. This protein is involved in cleavage of endothelin-3.;

NCIt note : Kell blood group glycoprotein is covalently linked to membrane transport protein XK. Lack of XK protein is associated with the McLeod phenotype of the Kell blood group system. (OMIM); Kell can cleave endothelins 1, 2 and 3 but has a preference for endothelin-3. (UniProt);

Details

Origin ID

C147986;

UMLS CUI

C3710659;

Automatic exact mappings (from CISMeF team)
- Blood group--kell system [OMIM Phenotype]
- Kell blood group metalloendopeptidase [OMIM gene]
- Kell blood group, metallo-endopeptidase [ORDO Gene]
- Kell group Ag [LOINC component]
OMIM relation
- Kell blood group metalloendopeptidase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- KEL protein, human [MeSH Supplementary Concept]
- KEL protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- KEL Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Protein Cleavage [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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