" /> Blood group--kell system - CISMeF





Preferred Label : Blood group--kell system;

Symbol : KEL;

CISMeF acronym : KEL; K(0);

Type : Phenotype, molecular basis known;

Alternative titles and symbols : Blood group--kell-cellano system;

Included titles and symbols : Kell-null; K(0); Ko;

Description : The Kell blood group system is formed by 2 disulfide-linked proteins, Kell and XK. The Kell protein is a type II membrane glycoprotein sharing sequence homology with members of the M13 family of zinc-dependent metalloproteases and possessing enzymatic activity characteristic of that group (summary by Claperon et al., 2007). The Kell blood group system is highly polymorphic, expressing over 25 antigens that have been classified in to 5 antithetical sets of high and low prevalence antigens with the others being independently expressed or having unknown antithetical partners. The different phenotypes are due to single-nucleotide mutations that result in an amino acid substitution (summary by Sha et al., 2006). See, for example, Kell (designated K or K1)/Cellano (k, K2) (T193M; 613883.0001). Yu et al. (2001) noted that the Kell antigens are the most potent immunogens aside from the A and B antigens of the ABO system (110300) and the D antigen (111680) of the Rh system (see 111700).;

Prefixed ID : #110900;

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14/05/2024


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