Retifanlimab - CISMeF

Preferred Label : Retifanlimab;

NCIt synonyms : Retifanlimab-dlwr;

NCIt definition : A proprietary humanized monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, retifanlimab binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T-cells and cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity.;

UNII : 2Y3T5IF01Z;

CAS number : 2226345-85-1;

Drug name : Zynyz;

Molecule name : MGA 012; INCMGA00012; INCMGA 0012; INCMGA-0012; MGA-012;

NCI Metathesaurus CUI : CL540160;

Codes from synonyms : 114475;

Details

Origin ID

C142168;

UMLS CUI

C5401615;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- retifanlimab [ATC Code]
Validated automatic mappings to BTNT
- retifanlimab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Programmed Cell Death Protein 1 [NCIt concept]
is_component_of_chemotherapy_regimen
- Retifanlimab Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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