" /> Retifanlimab - CISMeF





Preferred Label : Retifanlimab;

NCIt synonyms : Retifanlimab-dlwr;

NCIt definition : A proprietary humanized monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, retifanlimab binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T-cells and cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity.;

UNII : 2Y3T5IF01Z;

CAS number : 2226345-85-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2226345-85-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Zynyz;

Molecule name : MGA 012; INCMGA00012; INCMGA 0012; INCMGA-0012; MGA-012;

NCI Metathesaurus CUI : CL540160;

Codes from synonyms : 114475;

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12/05/2024


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