Maternal Embryonic Leucine Zipper Kinase

Preferred Label : Maternal Embryonic Leucine Zipper Kinase;

NCIt synonyms : Protein Kinase Eg3; Tyrosine-Protein Kinase MELK; hMELK; Protein Kinase PK38; pEg3 Kinase; hPK38;

NCIt definition : Maternal embryonic leucine zipper kinase (651 aa, 75 kDa) is encoded by the human MELK gene. This protein plays a role in the mediation of protein phosphorylation that regulates cell cycle, cell death and cell proliferation.;

NCI Metathesaurus CUI : CL523824;

Details

Origin ID

C134700;

UMLS CUI

C4521276;

Automatic exact mappings (from CISMeF team)
- Maternal embryonic leucine zipper kinase [OMIM gene]
- maternal embryonic leucine zipper kinase [HGNC gene]
OMIM relation
- Maternal embryonic leucine zipper kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- MELK Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
- UBA Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- MELK Inhibitor OTS167 [NCIt concept]

Keyword's position in hierarchy(ies) :

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