Egl Nine Homolog 2

Preferred Label : Egl Nine Homolog 2;

NCIt synonyms : HIF-PH1; Prolyl Hydroxylase Domain-Containing Protein 1; HIF Prolyl Hydroxylase 1; Estrogen-Induced Tag 6; HIF Prolyl 4-Hydroxylase 1; Hypoxia-Inducible Factor Prolyl Hydroxylase 1; HIF-Prolyl Hydroxylase 1; HPH-1; PHD1; Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 1; HPH-3; EC 1.14.11.29; EGLN2;

NCIt definition : Egl nine homolog 2 (407 aa, 44 kDa) is encoded by the human EGLN2 gene. This protein is involved in the hydroxylation of hypoxia-inducible factor alpha proteins.;

NCIt note : Egl nine homolog 2 activity may be associated with chemotherapy resistance in colorectal carcinoma. (EMBO Molecular Medicine. 2015; 7:1350-1365.);

Details

Origin ID

C131540;

UMLS CUI

C1310406;

Automatic exact mappings (from CISMeF team)
- Egl9 family hypoxia-inducible factor 2 [OMIM gene]
- Hypoxia-Inducible Factor-Proline dioxygenases [MeSH Descriptor]
- Hypoxia-Inducible factor prolyl hydroxylase 1 [MeSH concept]
- Polyhomeotic homolog 1 [OMIM gene]
- egl-9 family hypoxia inducible factor 2 [HGNC gene]
- polyhomeotic homolog 1 [ORDO Gene]
OMIM relation
- Egl9 family hypoxia-inducible factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- EGLN2 protein, human [MeSH Supplementary Concept]
- EGLN2 protein, human [MeSH concept]
gene_encodes_gene_product
- EGLN2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Stress Response [NCIt concept]
- Homeostatic Process [NCIt concept]
- Iron Chelation [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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