O6-Benzylguanine

Preferred Label : O6-Benzylguanine;

NCIt synonyms : O-6-Benzylguanine; O 6 Benzylguanine; 2-amino-6-(phenylmethoxy)-9h-purine; 2-amino-6-(benzyloxy)purine;

NCIt related terms : 6-O-BENZYLGUANINE; O(6)-benzylguanine;

NCIt definition : A guanine analogue with antineoplastic activity. O6-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. (NCI04);

Alternative definition : NCI-GLOSS: A drug that may improve the response of cancer cells to chemotherapy.;

UNII : 01KC87F8FE;

InChIKey : KRWMERLEINMZFT-UHFFFAOYSA-N;

CAS number : 19916-73-5;

Molecule name : O6-BG;

Chemical formula : C12H11N5O;

NSC code : 637037;

Codes from synonyms : CDR0000046040; NSC0637037;

Details

Origin ID

C1306;

UMLS CUI

C0083812;

Currated CISMeF NLP mapping
- O(6)-benzylguanine [MeSH concept]
- O(6)-benzylguanine [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- O(6)-benzylguanine [MeSH Supplementary Concept]
- O(6)-benzylguanine [MeSH concept]
chemical_or_drug_affects_gene_product
- Alkyltransferase and Aryltransferase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Repair Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Methylated-DNA-Protein-Cysteine Methyltransferase [NCIt concept]
is_component_of_chemotherapy_regimen
- Carmustine/O6-Benzylguanine [NCIt concept]
- O6-Benzylguanine/Polifeprosan 20 With Carmustine Implant [NCIt concept]
- O6-benzylguanine/Temozolomide [NCIt concept]

Keyword's position in hierarchy(ies) :

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