NCIt synonyms : O-6-Benzylguanine; O 6 Benzylguanine; 2-amino-6-(phenylmethoxy)-9h-purine; 2-amino-6-(benzyloxy)purine;
NCIt related terms : 6-O-BENZYLGUANINE; O(6)-benzylguanine;
NCIt definition : A guanine analogue with antineoplastic activity. O6-benzylguanine binds the DNA repair
enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety
to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair.
Co-administration of this agent potentiates the effects of other chemotherapeutic
agents that damage DNA. (NCI04);
Alternative definition : NCI-GLOSS: A drug that may improve the response of cancer cells to chemotherapy.;
UNII : 01KC87F8FE;
InChIKey : KRWMERLEINMZFT-UHFFFAOYSA-N;
CAS number : 19916-73-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 19916-73-5
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