Emapalumab - CISMeF

Preferred Label : Emapalumab;

NCIt synonyms : Anti-IFN gamma Monoclonal Antibody NI-0501; Anti-IFNg mAb NI-0501; Anti-interferon gamma Monoclonal Antibody NI-0501; Emapalumab-lzsg;

NCIt definition : A human monoclonal antibody against the cytokine interferon-gamma (IFN-gamma; IFNg), with potential immunomodulating activity. Upon administration, emapalumab binds to and neutralizes IFNg. This inhibits IFNg-mediated signaling pathways and suppresses the activation of the immune system. IFNg, a cell-signaling protein, plays a key role in the regulation and activation of the immune system; its upregulation is associated with certain auto-immune and auto-inflammatory diseases in which the immune system is abnormally activated.;

UNII : 3S252O2Z4X;

CAS number : 1709815-23-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1709815-23-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Gamifant;

Molecule name : NI-0501;

NCI Metathesaurus CUI : CL507913;

Codes from synonyms : 46354;

Details

Origin ID

C127123;

UMLS CUI

C4740904;

Automatic exact mappings (from CISMeF team)
- Emapalumab [ICD-11 Extension code]
- Emapalumab [MeSH concept]
Currated CISMeF NLP mapping
- Emapalumab [MeSH Supplementary Concept]
- Emapalumab (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing emapalumab (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Emapalumab [MeSH Supplementary Concept]
- Emapalumab (substance) [SNOMED CT concept]
- Product containing emapalumab (medicinal product) [SNOMED CT concept]
- emapalumab [ATC Code]
Validated automatic mappings to BTNT
- emapalumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Interferon Gamma [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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