NCIt definition : A human monoclonal antibody against the cytokine interferon-gamma (IFN-gamma; IFNg),
with potential immunomodulating activity. Upon administration, emapalumab binds to
and neutralizes IFNg. This inhibits IFNg-mediated signaling pathways and suppresses
the activation of the immune system. IFNg, a cell-signaling protein, plays a key role
in the regulation and activation of the immune system; its upregulation is associated
with certain auto-immune and auto-inflammatory diseases in which the immune system
is abnormally activated.;