Dostarlimab - CISMeF

Preferred Label : Dostarlimab;

NCIt synonyms : Immunoglobulin G4, Anti-programmed Cell Death Protein 1 (PDCD1) (Humanized Clone ABT1 Gamma4-chain), Disulfide with Humanized Clone ABT1 Kappa-chain, Dimer; Dostarlimab-gxly;

NCIt definition : A humanized monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1; programmed death-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, dostarlimab binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T-cells. PD-1, a transmembrane protein in the Ig superfamily expressed on T-cells, functions as an immune checkpoint protein that negatively regulates T-cell activation and T-cell-mediated immune responses when activated by its ligands programmed cell death receptor ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity.;

UNII : P0GVQ9A4S5;

CAS number : 2022215-59-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2022215-59-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Jemperli;

Molecule name : TSR-042; ANB011; TSR 042;

NCI Metathesaurus CUI : CL1676862;

Codes from synonyms : 34976;

Details

Origin ID

C126799;

UMLS CUI

C5242455;

Automatic exact mappings (from CISMeF team)
- dostarlimab-gxly [MeSH concept]
Manual BTNT mappings - CISMeF
- dostarlimab [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dostarlimab (substance) [SNOMED CT concept]
- Product containing dostarlimab (medicinal product) [SNOMED CT concept]
- dostarlimab [ATC Code]
- dostarlimab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Programmed Cell Death Protein 1 [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Dostarlimab/Paclitaxel Regimen [NCIt concept]
- Dostarlimab Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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