Preferred Label : Oxaliplatin;
NCIt synonyms : 1-OHP; oxalato (trans-l-1,2-diaminocyclohexane)platinum(II); [(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum; oxalato (1R,2R-cyclohexanediamine)platinum(II); [SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinum; Diaminocyclohexane Oxalatoplatinum; trans-l diaminocyclohexane oxalatoplatinum; trans-l DACH oxalatoplatinum;
NCIt related terms : ELOXATIN; Oxalatoplatin; Oxalatoplatinum; DACPLAT; RP 54780;
NCIt definition : An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane
(DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom
or a group of atoms that is displaced as a stable species taking with it the bonding
electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin
derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming
both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of
DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH
side chain appears to inhibit alkylating-agent resistance. (NCI04);
Alternative definition : NCI-GLOSS: A drug used with other drugs to treat colorectal cancer that is advanced
or has come back. It is also being studied in the treatment of other types of cancer.
Eloxatin attaches to DNA in cells and may kill cancer cells. It is a type of platinum
compound.;
UNII : 04ZR38536J;
InChIKey : ZROHGHOFXNOHSO-BNTLRKBRSA-L;
CAS number : 61825-94-3;
Drug name : Dacotin; Dacplat; Eloxatine; Eloxatin; Aiheng; Ai Heng; Elplat;
Molecule name : SR-96669; RP-54780; JM-83; JM 83; SR 96669;
Chemical formula : C8H14N2O4Pt;
NSC code : 266046;
ChEBI ID : CHEBI:31941;
Codes from synonyms : NSC0266046; CDR0000413944; CDR0000045465; 377;
Origin ID : C1181;
UMLS CUI : C0069717;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
https://pgtmsite.files.wordpress.com/2024/01/oxaliplatine_ad_et_rum_20070515.pdf
2007
Canada
drug information
Analyzed
Use
Oxaliplatin
Analysis
Oxaliplatin
Review
---
https://pgtmsite.files.wordpress.com/2024/01/oxaliplatine_colonadjuvant_pgtm_20050930.pdf
2005
Canada
drug information
cancer of colon
Oxaliplatin
Adjuvant
neoplasm, malignant
Adjuvant Therapy Clinical Trial Setting
Oxaliplatin
large intestine, nos
colonic neoplasms
Colon Carcinoma
Additive
Adjudicator
adjuvant, nos
---
