Oxaliplatin - CISMeF

Preferred Label : Oxaliplatin;

MeSH definition : An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.;

MeSH synonym : 1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II); Platinum(II)-1,2-cyclohexanediamine Oxalate; Oxalato-(1,2-cyclohexanediamine)platinum II; Oxaliplatin, (SP-4-2-(1R-trans))-isomer; Oxaliplatine; 1,2-Diaminocyclohexane Platinum Oxalate; 1,2 Diaminocyclohexane Platinum Oxalate; L-OHP Cpd; Platinum(2 ) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1);

MeSH hyponym : ACT-078; ACT078;

MeSH CAS label : Platinum(2 ) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1);

MeSH Related Number : 61758-77-8 ((SP-4-2-(1S-trans))-isomer); 61913-68-6 ((SP-4-3-(cis))-isomer);

UNII : 04ZR38536J;

Details

Origin ID

D000077150;

UMLS CUI

C0069717;

ATC code(s)
- oxaliplatin [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Oxaliplatin [ICD-11 Extension code]
Pharmacological action(s)
- antineoplastic agents [MeSH Descriptor]
Record concept(s)
- ACT 078 [MeSH concept]
- Eloxatin [MeSH concept]
- cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II) [MeSH concept]
- eloxatine [MeSH concept]
- oxaliplatin [MeSH concept]
- oxaliplatin, (SP-4-2-(1S-trans))-isomer [MeSH concept]
- oxaliplatin, (SP-4-3-(cis))-isomer [MeSH concept]
Related MeSH Supplementary Concept(s)
- folfirinox [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing oxaliplatin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to BTNT
- oxaliplatin [ATC Code]

Keyword's position in hierarchy(ies) :

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