" /> Leflunomide - CISMeF





Preferred Label : Leflunomide;

NCIt synonyms : 4-Isoxazolecarboxamide, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-;

NCIt related terms : SU101;

NCIt definition : A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that works by inhibiting a cancer cell growth factor.;

UNII : G162GK9U4W;

InChIKey : VHOGYURTWQBHIL-UHFFFAOYSA-N;

CAS number : 75706-12-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 75706-12-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Arava;

Molecule name : SU101;

Chemical formula : C12H9F3N2O2;

NSC code : 677411;

ChEBI ID : CHEBI:6402;

Codes from synonyms : CDR0000045436; NSC0677411; CDR0000046000;

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14/05/2024


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