Preferred Label : Leflunomide;

NCIt synonyms : 4-Isoxazolecarboxamide, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-;

NCIt related terms : SU101;

NCIt definition : A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that works by inhibiting a cancer cell growth factor.;

UNII : G162GK9U4W;

InChIKey : VHOGYURTWQBHIL-UHFFFAOYSA-N;

CAS number : 75706-12-6;

Drug name : Arava;

Molecule name : SU101;

Chemical formula : C12H9F3N2O2;

NSC code : 677411;

ChEBI ID : CHEBI:6402;

Codes from synonyms : CDR0000045436; NSC0677411; CDR0000046000;

Details


Keyword's position in hierarchy(ies) : arborescence

Main resources

You can consult :


https://www.rheuma-net.ch/fr/doc/leflunomid-1/viewdocument/351
2024
Switzerland
guideline
Background Treatment
Leflunomide
Leflunomide

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12/05/2025


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