Leflunomide - CISMeF

Preferred Label : Leflunomide;

MeSH definition : An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.;

MeSH synonym : N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide;

MeSH hyponym : HWA-486; HWA486;

MeSH CAS label : 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-;

MeSH Related Number : 75706-12-6 (Leflunomide);

UNII : G162GK9U4W;

Details

Origin ID

D000077339;

UMLS CUI

C0063041;

ATC code(s)
- leflunomide [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- leflunomide [Substance BNPC]
MeSH indexing information
- adjuvants, immunologic [MeSH Descriptor]
- anti-inflammatory agents, non-steroidal [MeSH Descriptor]
- antineoplastic agents [MeSH Descriptor]
- antiviral agents [MeSH Descriptor]
Pharmacological action(s)
- enzyme inhibitors [MeSH Descriptor]
- immunosuppressive agents [MeSH Descriptor]
Record concept(s)
- HWA 486 [MeSH concept]
- SU101 [MeSH concept]
- arava [MeSH concept]
- leflunomide [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to BTNT
- leflunomide [ATC Code]

Keyword's position in hierarchy(ies) :

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