Apolipoprotein B-100

Preferred Label : Apolipoprotein B-100;

NCIt synonyms : APOB; ApoB-100; Apo B-100;

NCIt definition : Apolipoprotein B-100 (4563 aa, 516 kDa) is encoded by the human APOB gene. This protein plays a role in both transport and cellular uptake of LDL particles.;

NCIt note : RNA editing of the full-length APOB transcript at residue 2180 (CAA- UAA), results in the creation of a stop codon. This truncated mRNA encodes apolipoprotein B-48 (apo B-48), which is found in chylomicron particles. (EntrezGene and UniProt);

Details

Origin ID

C106032;

UMLS CUI

C3252643;

Automatic exact mappings (from CISMeF team)
- Apo-B [MedDRA LLT]
- Apolipoprotein B [LOINC component]
- Apolipoprotein B [MedDRA Preferred Term]
- Apolipoprotein B-100 [LOINC component]
- Apolipoprotein B-100 (substance) [SNOMED CT concept]
- Apolipoprotein b [OMIM gene]
- apolipoprotein B [ORDO Gene]
- apolipoprotein B-100 [MeSH concept]
- apolipoprotein b-100 [MeSH Descriptor]
- apolipoprotein b-100 [SNOMED Notion]
- apolipoproteins b [MeSH Descriptor]
OMIM relation
- Apolipoprotein b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- APOB protein, human [MeSH Supplementary Concept]
- APOB protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- APOB Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
gene_product_has_biochemical_function
- Lipoprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- FOXA1 Transcription Factor Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- High Density Lipoprotein [NCIt concept]
gene_product_plays_role_in_biological_process
- Cholesterol Homeostasis [NCIt concept]
- Ligand Binding [NCIt concept]
- Lipid Transport [NCIt concept]
- Transport Process [NCIt concept]
- Triglyceride Metabolism [NCIt concept]

Keyword's position in hierarchy(ies) :

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