Calprotectin - CISMeF

Preferred Label : Calprotectin;

NCIt synonyms : MRP-8/MRP-14 Complex; Leukocyte L1 Complex; S100A8/S100A9 Complex; S100A8/A9 Complex;

NCIt definition : A heterodimeric or heterotetrameric protein complex comprised of protein S100A8 and protein S100A9. This complex is expressed in the cytosol of neutrophils and macrophages and plays a role in multiple host defense related processes including immunomodulation, neutrophil chemotaxis and both antibacterial and antifungal responses.;

NCIt note : Elevated levels of calprotectin may be associated with chronic inflammatory diseases.;

Details

Origin ID

C105971;

UMLS CUI

C0950624;

Automatic exact mappings (from CISMeF team)
- S100 calcium-binding protein a8 [OMIM gene]
- S100 calcium-binding protein a9 [OMIM gene]
Currated CISMeF NLP mapping
- Calprotectin [LOINC component]
- Calprotectin (substance) [SNOMED CT concept]
- calprotectin [COVID-19 Thesaurus concept]
- calprotectin [EMDN type]
- calprotectin [medical devices type]
- leukocyte L1 antigen complex [MeSH concept]
- leukocyte l1 antigen complex [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Calprotectin [LOINC component]
- Calprotectin (substance) [SNOMED CT concept]
- leukocyte L1 antigen complex [MeSH concept]
- leukocyte l1 antigen complex [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
has_gene_product_element
- Protein S100-A8 [NCIt concept]
- Protein S100-A9 [NCIt concept]
related_to_genetic_biomarker
- S100A8 Gene [NCIt concept]
- S100A9 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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