Preferred Label : calprotectin;
Definition : Calprotectin is a complex of the mammalian proteins S100A8 and S100A9. In the presence
of calcium, calprotectin is capable of sequestering the transition metals iron, manganese
and zinc via chelation. This metal sequestration affords the complex antimicrobial
properties. Calprotectin is the only known antimicrobial manganese sequestration protein
complex. Calprotectin comprises as much as 60% of the soluble protein content of the
cytosol of a neutrophil, and it is secreted by an unknown mechanism during inflammation.
(Wikipedia);
Synonyme : antigen l1, myelomonocytic; antigen, 27e10; calcium binding myeloid protein p8,14; leukocyte l1 antigen complex; 27e10 antigen; myelomonocytic antigen l1; calgranulin; migratory inhibitory factor related protein mrp; leukocyte l1 protein; l1 antigen; antigen, l1; migratory inhibitory factor-related protein mrp; l1 protein, leukocyte; calcium-binding myeloid protein p8,14;
Origin ID : ZKKZN16B-8;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
Calprotectin is a complex of the mammalian proteins S100A8 and S100A9. In the presence
of calcium, calprotectin is capable of sequestering the transition metals iron, manganese
and zinc via chelation. This metal sequestration affords the complex antimicrobial
properties. Calprotectin is the only known antimicrobial manganese sequestration protein
complex. Calprotectin comprises as much as 60% of the soluble protein content of the
cytosol of a neutrophil, and it is secreted by an unknown mechanism during inflammation.
(Wikipedia)
