Neutrophil Elastase

Preferred Label : Neutrophil Elastase;

NCIt synonyms : Elastase, Neutrophil Expressed; EC 3.4.21.37; Granulocyte-Derived Elastase; Polymorphonuclear Elastase; Medullasin; Human Leukocyte Elastase; Elastase 2; Leukocyte Elastate; Bone Marrow Serine Protease; PMN Elastase; Elastase 2, Neutrophil; ELANE;

NCIt definition : Neutrophil elastase (267 aa, 29 kDa) is encoded by the human ELANE gene. This protein plays a role in innate host defense and tissue remodeling.;

Details

Origin ID

C104198;

UMLS CUI

C4551701;

Automatic exact mappings (from CISMeF team)
- Elastase, neutrophil-expressed [OMIM gene]
- elastase, neutrophil expressed [ORDO Gene]
- elastase, neutrophil expressed [HGNC gene]
- medullasin [MeSH concept]
- medullasin [MeSH Supplementary Concept]
- pancreatic elastase II [MeSH Supplementary Concept]
OMIM relation
- Elastase, neutrophil-expressed [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ELANE protein, human [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- Elastase.leukocyte [LOINC component]
- Leukocyte elastase (substance) [SNOMED CT concept]
- leukocyte elastase [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ELANE Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- Alvelestat [NCIt concept]

Keyword's position in hierarchy(ies) :

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